Nanobiotechnology: A Promising Future

Nanobiotechnology, The Intersection of Sciences

Nanotechnology, which can be defined as the capacity to synthesize, manipulate and visualize matter at the nanometer scale, had a starting point in the 1980s. The usage of the “nanoparticle” term is broad and comprises both organic and inorganic nanomaterials. Lipids and biopolymers fall within the organic nanomaterials category, while non-spherical metals, oxides, and carbon are considered inorganic nanomaterials.

The nexus of nanotechnology and biotechnology is called nanobiotechnology. Nanobiotechnology is applied in life sciences for various use cases, ranging from new molecular imaging techniques for early-stage diagnosis of diseases and therapy aftereffects, to drug delivery in pharmacology. Nanobiotechnology is also used for quantitative analytical tools at the molecular level, as well as for the improvement of laboratory techniques concerning ex vivo. While most studies are still a work in progress for research laboratories, nano-based treatments, vaccines, drugs, and diagnostic devices are gradually being approved for commercialization and clinical use.

Nanobiotechnology in Immunotherapy and Public Health

One of the most desirable aspects of nanotechnology is its stability, which also serves as a solubility-enhancing technique. Smaller particles allow the ratio of surface area to volume to increase, resulting in a higher solubility. A substance's solubility affects its ability to penetrate biological membranes and achieve the intended effect. This knowledge in nanobiotechnology is especially essential for medicinal studies as a key area of interest.

A significant concern for government agencies and health professionals worldwide is the issue of bacterial and fungal resistance. Traditional methods with oral and intravenous drugs pose several challenges such as adverse side effects, the need for increasing doses, and antibacterial drug resistance. Due to these issues, the need to increase the effectiveness of antimicrobial therapies has never been higher.

Enter nanomaterials. Nanomaterials can potentiate the efficacy of both existing and novel drug therapies. By leveraging the unique properties and dimensions of nanomaterials, researchers aim to overcome drug resistance and provide more effective treatments through controlled, targeted delivery, and drugs that can force through biofilms in wounds which conventional treatments are unable to breach.

In addition to combating antibiotic resistance, nanomedicines have a range of diverse applications, such as in the treatment of cancer, tuberculosis, and neurodegenerative diseases. Such innovations are set to revolutionize immunotherapy, with new developments like 'vaccine implants' that continuously modulate and enhance immune responses without the need for repeated administrations. These could lead to significant advancements in public health by providing more effective and long-lasting treatments for a variety of diseases.

Understanding Nanotoxicology

As the study of nanomaterials advances, it is important to understand the toxicity of nanomaterials to unlock nanobiotechnology's true potential. While nanomaterials are appealing for a wide range of medical applications due to their ability to penetrate tissues, cells, physical barriers, and their reach to vital organs, their benefits are not entirely free of adverse effects. Nanomaterials use can lead to cell apoptosis, inflammation, exacerbation of asthma, fibrosis, chronic inflammatory lung diseases, and carcinogenesis. Two decades of research has shown that interactions between nanomaterials and microorganisms as well as their ecosystems are complex.

To address these risks, understanding and mitigating nanotoxicity should be enforced as a form of responsible research and innovation. Additionally, collaboration between scientists, pharmaceutical industry, regulators and governments are crucial to balance innovation with safeguarding public health. This collective effort will assist the medical community in navigating the complexities of nanobiotechnology to deliver scientific breakthroughs effectively and responsibly.

Precision and Safety in Nanobiotechnology

Esco Lifesciences LA2 G4 Biosafety Cabinet provides a contamination-free and controlled environment crucial for handling nanoparticles and sensitive nanomaterials. This ensures the integrity and safety of experiments involving nanoparticle synthesis, manipulation, and analysis, which is essential for developing targeted drug delivery sytems and nanomedicines. Our CCL-170B CO₂ Incubator also offers a stable, precise environment for cell cultures, vital for nanobiotechnology applications like cancer therapies and antimicrobial studies. Its advanced CO₂ control and temperature regulation create optimal conditions for growing cells used in nanomedicine research, enhancing the efficiency and reliability of nanomaterial-based treatments. Together, these products safeguard both the research and researchers, ensuring precise and contamination-free experimentation in nanotechnology.

Biosafety Cabinet, LA2 G4
Labculture® G4 (LA2 G4), available in three sash height openings (8”, 10”, and 12” inches), is NSF-certified and provides an ergonomic work zone. Comprised of bright illumination using industry-leading dimmable LED combined with raised, durable, stainless-steel armrest and large, recessed, spill-containing work tray, this biological safety cabinet is devised for optimum work comfort even for sensitive procedures that require precision such as nanomaterial manipulation. Its ULPA filtration system also makes it ideal for nanomaterial handling due to its high-level contamination control. Learn More Request for Quote	Features: Centurion Touchscreen Controller Intuitive, comprehensive, and easy-to-understand Virtually comprehensible safety information and cabinet alarms via 3D BSC diagram Defined details of alarm types with clear instructions for proper intervention Centered and angled down for easy reach & viewing Selectable Quickstart mode for fast operation Dimmable LED Adjustable work zone brightness Ideal light intensity of 1200 lux Saves energy and optimizes work comfort Ergonomic Sash Available in 8”, 10”, and 12” sash openings Frameless, shatterproof, and UV-absorbing tempered glass Tray support beams and holder Support beams for less vibration and holder for easy drain pan cleaning USB Port and Remote Modbus USB port to access cabinet data log and BMS connectivity Newly integrated Remote Modbus feature for users to securely access the cabinet remotely from external devices Cabinet Construction Stainless steel side walls with side capture zones and negative pressure to optimize containment Single-piece work tray, spill retaining and easy to clean Green Product Equipped with energy-efficient DC ECM that allows up to 70% energy savings vs AC motor Extremely low energy consumption with 205 watts (4 ft unit) Standby mode allows reduced power consumption by 80% ULPA Filter 10x filtration efficiency compared to the HEPA filter Creates ISO Class 3 work zone instead of industry-standard, ISO Class 5 Same 10 years filter life and replacement cost as HEPA filters *99.999% at 0.1 to 0.3 micron, ULPA as per IEST-RP-CC001.3 USA *99.999% at MPPS, H14 as per EN 1822 EU Isocide™ Antimicrobial Powder Coating Eliminates 99.9% of surface bacteria within 24 hours of exposure
CO2 Incubator, CCL-170B
The CelCulture® CO2 incubator is designed to empower cell culture laboratory through comprehensive sample protection that helps scientists achieve their research goals. From robust contamination control specifically for delicate nanomaterials to stability maintenance provided by the device's direct heat and air jacket, the CelCulture® CO2 incubator has a range of features that provide the necessary controlled environment for nanobiotechnology research. Learn More Request for Quote	Features: Robust Contamination Control SteriSafe™ ULPA filtration ensures ISO Class 5 air chamber cleanliness SwiftCon™ 90˚C validated moist heat decontamination cycle (15 hours) In-line filters remove gas impurities and contaminants Direct Heat and Air Jacket Fast and uniform heating Rapid temperature recovery Air jacket improves chamber stability Shelving Perforated shelving to improve uniformity Anti-tip Stainless steel Built-in grip Rounded Corners Seamless design Facilitates easier cleaning CO2 Sensor IR Sensor Single-beam, dual-wavelength IR sensor is drift-free CARBOCAP® technology makes it stable for a long time and resistant to high heat Isocide™ Antimicrobial Powder Coating Eliminates 99.9% of surface bacteria within 24 hours of exposure